(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid - Names and Identifiers

Name	(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid
Synonyms	(4S,5R)-3,5-Oxazolidinedicarbo (4S,5R)-5-Carboxy-2,2-Dimethyl-4-Phenyl-3-(Tert-Butoxycarbonyl)Oxazolidine (4S,5R)-3-(Tert-Butoxycarbonyl)-2,2-Dimethyl-4-Phenyloxazolidine-5-Carboxylic (4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic (4R,5S)-3-(Tert-Butoxycarbony)-2,2-Dimethyl-4-Phenyloxazolidine-5-Carboxylicacid (4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid (4S,5R)-N-(Tert-Butoxycarbonyl)-2,2-Dimethyl-4-Phenyl-5-Oxazolidinecarboxylic Acid (4S,5R)-3-(N-Tert-Butoxycarbonyl)-2,2-Dimethyl-4-Phenyloxazolidine-5-Carboxylic Acid (4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid (4S,5R)-3-(Tert-Butoxycarbonyl)-2,2-Dimethyl-4-Phenyl-1,3-Oxazolidine-5-Carboxylic Acid (4S,5R)-3,5-OXAZOLIDINEDICARBOXYLIC ACID-2,2-DIMETHYL-4-PHENYL-3-(1,1-DIMETHYLETHYL)ESTER (4S,5R)-3,5-Oxazolidinedicarboxylic Acid-2,2-Dimethyl-4-Phenyl-3-(1,1-Dimethylethyl)Ester (4S,5R)-2,2-Dimethyl-4-phenyl-3,5-oxazolidinedicarboxylic Acid 3-(1,1- Dimethylethyl) Ester (4S-Trans)-2,2-Dimethyl-4-Phenyl-3,5-Oxazolidinedicarboxylic Acid 3-(1,1-Dimethylethyl) Ester (4s-trans)-2,2-dimethyl-4-phenyl-3,5-oxazolidinedicarboxylic acid 3-(1,1-dimethylethyl) ester 3,5-Oxazolidinedicarboxylic acid, 2,2-dimethyl-4-phenyl-, 3-(1,1-dimethylethyl) ester, (4S,5R)-
CAS	143527-70-2
EINECS	1806241-263-5
InChI	InChI=1/C17H23NO5/c1-16(2,3)23-15(21)18-12(11-9-7-6-8-10-11)13(14(19)20)22-17(18,4)5/h6-10,12-13H,1-5H3,(H,19,20)/t12-,13+/m0/s1

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid - Physico-chemical Properties

Molecular Formula	C17H23NO5
Molar Mass	321.37
Density	1.177
Melting Point	112.0 to 116.0 °C
Boling Point	459.0±45.0 °C(Predicted)
Flash Point	231.4°C
Solubility	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	off-white semi-solid
Color	White to Pale Brown
pKa	3.11±0.60(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.526
Physical and Chemical Properties	White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Taxus.

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid - Reference Information

overview

paclitaxel and docetaxel are highly effective, low toxic and broad-spectrum anticancer drugs, especially for gynecological tumors. therefore, it is the chemotherapy drug with the fastest growth in clinical usage. The side chain of paclitaxel C13 is slightly modified (that is, the benzoyl group of the side chain is changed to tert-butoxycarbonyl) to obtain the docetaxel side chain. The obtained paclitaxel and docetaxel side chains are coupled with bacatin III to obtain anti-cancer drugs paclitaxel and docetaxel respectively.

application

docetaxel side chain can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical medicine synthesis process, and can be used as docetaxel intermediate.

Last Update：2024-04-09 21:11:58

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

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Multiple Specifications

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(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

CAS: 143527-70-2

Molecular Formula: C17H23NO5

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid - Names and Identifiers

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid - Physico-chemical Properties

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid - Reference Information

Supplier List

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid Request for Quotation

(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

CAS: 143527-70-2

Molecular Formula: C17H23NO5

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid - Names and Identifiers

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid - Physico-chemical Properties

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid - Reference Information

Supplier List

(4S,5R)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid